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CanniMed Therapeutics Inc.

Independent Laboratory Analysis Confirms CanniMed Medical Cannabis Products Free from Pesticides, Fungicides, and Plant Growth Regulators

SASKATOON, Saskatchewan [February 22, 2017]: CanniMed Therapeutics Inc. (TSX: CMED) proactively commissioned an independent laboratory analysis of the Company’s herbal cannabis products to test for 56 known pesticides, fungicides and PGRs (plant growth regulators). Each analyzed lot returned a clean Certificate of Analysis with “not detected” levels for each of the 56 pesticides, fungicides and PGRs.

“CanniMed Therapeutics has never, and will not in the future need to use pesticides, fungicides or PGRs in the manufacturing of our medical cannabis products because we follow a strict GMP process, following 281-points of quality control,” said Brent Zettl, President and CEO, CanniMed Therapeutics Inc. “By commissioning this evaluation, we looked to demonstrate to patients, physicians and investors how our GMP-compliant production process ensures cleanliness and prevention, resulting in products that can be trusted to be free from all contaminants.”

CMED commissioned Anandia Labs, Canada’s leading cannabis genetics and testing facility founded by internationally-recognized cannabis scientist Dr. Jonathan Page for this important analysis. Four lots of CMED’s proprietary strains (CanniMed® 22·1, CanniMed® 12·0, CanniMed® 9·9 and CanniMed® 1·13) were analyzed and each were awarded a clean Certificate of Analysis.

“Anandia Labs uses highly sensitive LC-MS/MS methods to identify and quantify the main pesticides and PGRs of known concern in cannabis, including myclobutanil, bifenazate and paclobutrazol,” said Dr. Jonathan Page, President and CEO, Anandia Labs. “Our lab has been at the forefront of cannabis-relevant pesticide testing and I am pleased that Anandia Labs was chosen by a leading Licensed Producer such as CanniMed Therapeutics to provide independent testing services to help ensure patient safety.”

About CanniMed Therapeutics Inc.

The Company is a Canadian-based, international plant biopharmaceutical company and a leader in the Canadian medical cannabis industry, with 15 years of pharmaceutical cannabis cultivation experience, state-of-the-art, GMP-compliant plant production processes and world class research and development platforms with a wide range of pharmaceutical-grade cannabis products. In addition, the Company has an active plant biotechnology research and product development program focused on the production of plant-based materials for pharmaceutical, agricultural and environmental applications.

CanniMed Ltd., a wholly-owned subsidiary of the Company, was the first producer to be licensed under the Marihuana for Medical Purposes Regulations, the predecessor to the current Access to Cannabis for Medical Purposes Regulations.

Prairie Plant Systems Inc., a wholly-owned subsidiary of the Company, was the sole supplier to Health Canada under the former medical marijuana system for 13 years, and has been producing safe and consistent medical marijuana for thousands of Canadian patients, with no incident of diversion.

For more information, please visit our websites: www.cannimed.ca (patients) and www.CanniMedTherapeutics.com ( investors).

Notice Regarding Forward Looking Statements

This news release contains forward-looking statements within the meaning of applicable securities laws. All statements that are not historical facts, including without limitation, statements regarding future estimates, plans, programs, forecasts, projections, objectives, assumptions, expectations or beliefs of future performance, are “forward-looking statements”. Forward-looking statements can be identified by the use of words such as “plans”, “expects” or “does not expect”, “is expected”, “estimates”, “intends”, “anticipates” or “does not anticipate”, or “believes”, or variations of such words and phrases or state that certain actions, events or results “may”, “could”, “would”, “might” or “will” be taken, occur or be achieved.

Forward-looking statements are based on assumptions and involve known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of CanniMed Therapeutics Inc. to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements, including the risks described in CanniMed Therapeutics Inc.’s documents filed with applicable Canadian securities regulatory authorities which may be viewed at sedar.com. The forward-looking statements included in this news release are made as of the date of this news release. CanniMed Therapeutics Inc. does not undertake to publicly update such forward-looking statements to reflect new information, subsequent events or otherwise, unless required by applicable securities legislation.

For more information, please contact:

Dara Willis
CanniMed Therapeutics Inc.
(416) 836-9272
media@cannimed.com

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CanniMed Therapeutics Inc. CTT Pharmaceutical Holdings Inc.

CTT Pharmaceutical Holdings and CanniMed Therapeutics Inc. Complete Exclusive Canadian Licensing Agreement for Cannabis Orally Dissolvable Thin Film (ODF) Wafer

SASKATOON, Saskatchewan and STONEY CREEK, Ontario [February 17, 2017]: Today, CanniMed Therapeutics Inc. (TSX: CMED) and CTT Pharmaceutical Holdings Inc. (OTCQB:CTTH) have entered into a definitive contractual relationship for the licensing of CTT’s Orally Dissolvable Thin Film (ODF) Wafer technology.

This industry-first collaboration includes the licensing of six patents related to cannabinoid and opioid delivery for pain management, which will enable CMED to exclusively develop and commercialize this novel, smoke-free, drug delivery system in Canada.

“The CanniMed ODF Wafers will complement the already well-integrated line of CanniMed® Oil products we have in market, broadening our ability to provide patients with standardized, dose-sensitive and discrete delivery systems,” said Brent Zettl, President and CEO, CanniMed Therapeutics Inc. “Collaborations with innovative companies such as CTT Pharma, and continued research and development into products that will further position medical cannabis as an important therapeutic option is a core focus of our company.”

Orally Dissolvable Thin Film (ODF) Wafers are a proprietary drug delivery mechanism in the form of paper-thin polymer films used as carriers for pharmaceutical agents, with the following benefits:

  • ODF Wafer is taken orally but does not require water or swallowing
  • ODF Wafers dissolve quickly in the oral cavity (5-15 seconds) with the active ingredient rapidly absorbed and diffused into the dense network of capillaries for direct access to the bloodstream via the oral mucosa.
  • The active ingredient, once absorbed, bypasses the liver’s first-pass effect, improving therapeutic outcomes and efficacy through improved bioavailability and facilitates excellent patient compliance
  • ODF Wafer is suitable for a wide range of patients, including for geriatric and pediatric patients who experience difficulty swallowing or patients who suffer from Phagophobia (fear of swallowing) or Pnigophobia (fear of choking)

“We are excited to announce the completion of our agreement with CanniMed Therapeutics; this is an excellent opportunity for us to marry our novel and patented delivery technology to CanniMed’s industry leading presence in the medical cannabis sector,” said Dr. Pankaj Modi, President and CEO, CTT Pharmaceutical Holdings. “We look forward to offering CanniMed’s existing patient population our convenient, smoke-free drug delivery system, which will help patients to take precise and accurate doses of cannabinoids as prescribed for pain management, mental disorders like depression, anxiety, post-traumatic stress disorder and a reduction in epileptic seizure syndromes in children. As the industry continues to grow and evolve we feel that we have chosen the right partner to introduce our product, tailor it to specific indications and to scale throughout Canada.”

Agreement Terms

Following the execution of the Licensing Agreement, CTT was paid $40,000USD by CMED. Upon issuance of the license from Health Canada to begin development of the OTF-cannabis wafer, CTT will be paid $935,000USD. CTT will also receive a royalty of 5 per cent based on gross sales. Additional payments will be made to CTT upon reaching certain milestones to be negotiated between the parties

The cost of development and manufacturing (including capital expenditures) has yet to be determined.

About CTT Pharmaceutical Holdings

CTT’s principal asset is a unique and novel patented drug delivery technology, an orally administered, fast dissolving thin film (the “Wafer”). This technology platform will target both the human and veterinarian (pet) markets for treatment of many diseases including pain management.

The Oral Thin Film (Wafer) formulation is protected by several Canadian and US Patents. CTT’s oral fast dissolving drug delivery systems will consist of edible thin films (wafers) that dissolve without water, within a few seconds after placement in the mouth. The majority of drugs administered using our drug delivery system mirror injections in that they have the ability to enter the bloodstream quickly, are convenient and discrete, and can be administered anywhere. A faster absorption rate is achieved because the mouth contains a very thin mucosa and is extremely vascular. There is no bitter taste, no smoke inhalation as is the case with cannabis, and less degradation of medication (by bypassing the stomach) and most importantly lower dosage units are required given the efficacy of absorption. Patient compliance is improved, especially with those who have a fear of choking and/or are pediatric, geriatric or incapacitated patients who have difficulty swallowing.

Most fast dissolving systems on the market today deliver anti-inflammatories, antihistamines and cough and breathing related medications. CTT believes that its Wafer technology will be one of the first to gain use in major markets such as pain management.

For more information, please visit our website: www.cttpharmaceuticals.com

About CanniMed Therapeutics Inc.

The Company is a Canadian-based, international plant biopharmaceutical company and a leader in the Canadian medical cannabis industry, with 15 years of pharmaceutical cannabis cultivation experience, state-of-the-art, GMP-compliant plant production processes and world class research and development platforms with a wide range of pharmaceutical-grade cannabis products. In addition, the Company has an active plant biotechnology research and product development program focused on the production of plant-based materials for pharmaceutical, agricultural and environmental applications.

CanniMed Ltd., a wholly-owned subsidiary of the Company, was the first producer to be licensed under the Marihuana for Medical Purposes Regulations, the predecessor to the current Access to Cannabis for Medical Purposes Regulations.

Prairie Plant Systems Inc., a wholly-owned subsidiary of the Company, was the sole supplier to Health Canada under the former medical marijuana system for 13 years, and has been producing safe and consistent medical marijuana for thousands of Canadian patients, with no incident of diversion.

For more information, please visit our websites: www.cannimed.ca (patients) and www.CanniMedTherapeutics.com ( investors).

Notice Regarding Forward Looking Statements

This news release contains forward-looking statements within the meaning of applicable securities laws. All statements that are not historical facts, including without limitation, statements regarding milestones, Health Canada approval, future additional payments, future estimates, plans, programs, forecasts, projections, objectives, assumptions, expectations or beliefs of future performance, are “forward-looking statements”. Forward-looking statements can be identified by the use of words such as “plans”, “expects” or “does not expect”, “is expected”, “estimates”, “intends”, “anticipates” or “does not anticipate”, or “believes”, or variations of such words and phrases or state that certain actions, events or results “may”, “could”, “would”, “might” or “will” be taken, occur or be achieved.

Forward-looking statements are based on assumptions and involve known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of CanniMed Therapeutics Inc. to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements, including the risk that Health Canada approval of the development of the OTF-cannabis wafer may be delayed or not issued or terms acceptable, the risk that CanniMed and CTT may be unable to agree to terms in respect of future milestones and additional payments, and the risks described in CanniMed Therapeutics Inc.’s documents filed with applicable Canadian securities regulatory authorities which may be viewed at sedar.com. The forward-looking statements included in this news release are made as of the date of this news release. CanniMed Therapeutics Inc. does not undertake to publicly update such forward-looking statements to reflect new information, subsequent events or otherwise, unless required by applicable securities legislation.

For further information, please contact:

Dara Willis
CanniMed Therapeutics Inc.
(416) 836-9272
media@cannimed.com

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CanniMed Therapeutics Inc. University of Manitoba

Trial Underway to Provide Scientific Validity of the Analgesic Efficacy and Safety of Medical Cannabis in an Experimental Autoimmune Encephalomyelitis (EAE) Animal Model of Multiple Sclerosis (MS)-Induced Neuropathic Pain

Saskatchewan and Manitoba [February 14, 2017]: As one of the major symptoms experienced by patients with Multiple Sclerosis (MS), neuropathic pain can be extremely debilitating. A leading neuro-immunology team lead by Dr. Michael Namaka at the University of Manitoba in Winnipeg, Manitoba, is looking to determine the analgesic efficacy of two of CanniMed Therapeutics Inc. (TSX: CMED) cannabinoid plant derived oil extracts using a rodent model of MS-induced neuropathic pain.

The study entitled “Identifying the molecular mechanisms involved in supressing multiple sclerosis induced neuropathic pain following cannabinoid treatment in an animal model of multiple sclerosis (MS)” will address the scientific merit of using medical cannabis in alleviating neuropathic pain.

Study Specifics: Experimental Autoimmune Encephalomyelitis (EAE) is a well-known animal model of MS. Dr. Namaka has several recent publications that demonstrate that EAE animals develop neuropathic pain following an immune system mediated insult such as an MS attack. i, ii, iii, iv, v, vi, vii In his publications, Dr. Namaka and others have shown that key biological targets such as TNFα and CX3CL1 increase during EAE-induced neuropathic pain. As such, EAE animals will receive analgesic treatment intervention with one of two cannabinoid oil extract products at a comparable oral dose that is used in humans to see if this medication can reduce the expression of these pathological molecules that drive chronic pain.

“This research endeavour will be the first pre-clinical scientific validation to identifying the direct molecular mechanisms of action of herbal medical cannabis oils and their direct potential impact on neuropathic pain for MS patients,” said Dr. Namaka, B.Sc. Pharm, M.Sc. Pharm, PhD; EPP, Associate Professor, College of Pharmacy, Rady Faculty of Health Sciences at the University of Manitoba. “With CanniMed’s ability to supply consistent, quality controlled and pharmaceutical-grade medical cannabis oils for this trial, we are confident that our outcomes will be standardized and provide us with direction on how cannabis oil will also respond in the patient population.”

This trial involves the investigation of two CanniMed® Oil products (CanniMed® 10:10; CanniMed® 1:20) to identify whether THC (tetrahydrocannabinol) and CBD (cannabidiol) together, or CBD alone, has an impact on MS-related neuropathic pain. The future goal of this pre-clinical study is to use these validated scientific findings to identify the lead cannabinoid oil extract that will move forward to a clinical trial involving human subjects with chronic pain.

“CanniMed is committed to working with leading physicians and researchers across Canada and around the world in the effort of identifying the potential impact of medical cannabis in supporting symptom management of a number of medical conditions,” said Brent Zettl, President and CEO, CanniMed Therapeutics Inc. “Research endeavours like this one will build upon the expanding library of pre-clinical and clinical research in order to demonstrate to patients, physicians, regulatory groups and governments that medical cannabis is an important therapeutic option.”

This study is currently underway and Dr. Namaka has indicated that the early preliminary results provide compelling scientific evidence to support the specific molecular mechanisms by which they exert their beneficial effects to suppress pain. These exciting results are expected to be submitted for publication within the next eight months.

CanniMed Therapeutics Inc. will invest $80,000 CDN in pre-clinical research funding to the University of Manitoba under the direction of Dr. Namaka to explore the molecular mechanisms that are responsible for the beneficial effects of cannabinoids in the treatment of multiple sclerosis-induced neuropathic pain.

About CanniMed Therapeutics Inc.

The Company is a Canadian-based, international plant biopharmaceutical company and a leader in the Canadian medical cannabis industry, with 15 years of pharmaceutical cannabis cultivation experience, state-of-the-art, GMP-compliant plant production processes and world class research and development platforms with a wide range of pharmaceutical-grade cannabis products. In addition, the Company has an active plant biotechnology research and product development program focused on the production of plant-based materials for pharmaceutical, agricultural and environmental applications.

CanniMed Ltd., a wholly-owned subsidiary of the Company, was the first producer to be licensed under the Marihuana for Medical Purposes Regulations, the predecessor to the current Access to Cannabis for Medical Purposes Regulations.

Prairie Plant Systems Inc., a wholly-owned subsidiary of the Company, was the sole supplier to Health Canada under the former medical marijuana system for 13 years, and has been producing safe and consistent medical marijuana for thousands of Canadian patients, with no incident of diversion.

Notice Regarding Forward Looking Statements

This news release contains forward-looking statements within the meaning of applicable securities laws. All statements that are not historical facts, including without limitation, the pre-clinical scientific validation of molecular mechanisms of action and statements regarding future estimates, plans, programs, forecasts, projections, objectives, assumptions, expectations or beliefs of future performance, are “forward-looking statements”. Forward-looking statements can be identified by the use of words such as “plans”, “expects” or “does not expect”, “is expected”, “estimates”, “intends”, “anticipates” or “does not anticipate”, or “believes”, or variations of such words and phrases or state that certain actions, events or results “may”, “could”, “would”, “might” or “will” be taken, occur or be achieved.

Forward-looking statements are based on assumptions and involve known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of CanniMed Therapeutics Inc. to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements, including the risk that the results of the study will not be conclusive and the risks described in CanniMed Therapeutics Inc.’s documents filed with applicable Canadian securities regulatory authorities which may be viewed at sedar.com. The forward-looking statements included in this news release are made as of the date of this news release. CanniMed Therapeutics Inc. does not undertake to publicly update such forward-looking statements to reflect new information, subsequent events or otherwise, unless required by applicable securities legislation.

For further information, please contact:

Dara Willis
CanniMed Therapeutics Inc.
(416) 836-9272
media@cannimed.com

Ilana Simon Director of Communications & Marketing,
Rady Faculty of Health Sciences, University of Manitoba
(204)789-3427
ilana.simon@umanitoba.ca


i Acosta, C., Cortes, C., Altaweel, K., MacPhee, H., Hoogervorst, B., Bhullar, H., MacNeil, B., Mahmoud Torabi, Burczynski, F., Namaka, M. (2015). Immune System Induction of Nerve Growth Factor in an Animal Model of Multiple Sclerosis: Implications in Re-myelination and Myelin repair. CNS & Neurological Disorders Drug Targets, 14 (8), 1069 - 78.

ii Khorshid Ahmad, T., Acosta, C., Cortes, C., Lakowski, T.M., Namaka, M. (2015). Transcriptional Regulation of Brain Derived Neurotrophic Factor (BDNF) by Methyl CpG Binding Protein 2 (MeCP2): A Novel Mechanism for Re-myelination and/or Myelin Repair Involved in the Treatment of Multiple Sclerosis (MS). Molecular Neurobiology, 53 (2), 1092 - 1107.

iii Turcotte, D. A., Doupe, M., Torabi, M., Gomori, A. J., Ethans, K., Esfahani, F., Galloway, K., Namaka, M. (2015). Nabilone as an Adjunctive to Gabapentin for Multiple Sclerosis - Induced Neuropathic Pain: A Randomized Controlled Trial. Pain Medicine, 16 (1), 149 - 59.

iv Zhu, W., Acosta, C., MacNeil, B.J., Cortes, C., Intrater, H., Gong, Y., Namaka, M. (2013). Elevated Expression of Fractalkine (CX3CL1) and Fractalkine receptor (CX3CR1) in the Dorsal Root Ganglia (DRG) and Spinal Cord (SC) in Experimental Autoimmune Encephalomyelitis (EAE): Implications in Multiple Sclerosis (MS) - Induced Neuropathic Pain (NPP). BioMed Research International, 2013 (September), doi: 10.1155/2013/480702.

v Begum, F., Zhu, W., Cortes, C., MacNeil, B. J., Namaka, M. P. (2013). Elevation of Tumor Necrosis Factor Alpha in Dorsal Root Ganglia and Spinal Cord is Associated with Neuroimmune Modulation of Pain in an Animal Model of Multiple Sclerosis. Journal of Neuroimmune Pharmacology, 8 (3), 677 - 90.

vi Zhu, W., Frost, E. E., Begum, F., Vora, P., Au, K., Gong, Y., MacNeil, B., Pillai, P., Namaka, M. (2012). The Role of Dorsal Root Ganglia Activation and Brain - Derived Neurotrophic Factor in Multiple Sclerosis. Journal of Cellular and Molecular Medicine, 16 (8), 1856 - 65.

vii Turcotte, D., Le Dorze, J.A., Esfahani, F., Frost, E., Gomori, A., Namaka, M. (2010). Examining the Roles of Cannabinoids in Pain and Other Therapeutic Indications. Expert Opinion on Pharmacotherapy, 11 (1), 17 - 31.

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CANNIMED THERAPEUTICS INC.

CANNIMED THERAPEUTICS INC. PROVIDES UPDATE ON PATIENT GROWTH RATES, SALES VOLUME AND PRODUCT SUPPLY

NOT FOR DISTRIBUTION TO U.S. NEWS WIRE SERVICES OR DISSEMINATION IN THE UNITED STATES.

Saskatoon, Saskatchewan [January 30, 2017] — CanniMed Therapeutics Inc. (TSX: CMED) (“CMED” or the “Company”), a leading plant biopharmaceutical company specializing in the production of pharmaceutical-grade cannabis, provides the following updates to shareholders related to patient growth rates, sales volumes and product supply.

The Offering was made through a syndicate of underwriters led by AltaCorp Capital Inc. and including Canaccord Genuity Corp., Clarus Securities Inc., Mackie Research Capital Corporation and Haywood Securities Inc.

CMED currently holds more than 20,000 patient records, with more than 11,000 active patients, defined as patients with a currently valid prescription on file.

January sales are the highest on record for the Company with 1,055 net new patient records contributing to total volume sales of 127 kilograms of dried marijuana equivalent sales, including 42 kilograms of dried marijuana equivalent sales of cannabis oils, which was generated from an average 255 orders per business day.

Prior to the January record, December 2016 was previously the highest volume month with 421 net new patients contributing to total volume sales of 110 kilograms of dried marijuana equivalent sales (including 34 kilograms of dried marijuana equivalent sales of cannabis oils) generated from an average of 216 orders per business day. The quarter is complemented by November 2016 with 182 net new patients contributing to total volume of sales of 103 kilograms of dried marijuana equivalent sales (including 29 kilograms of dried marijuana equivalent sales of cannabis oils), with an average 194 orders per business day.

“We are pleased with this significant month-over-month increase in new patients and volume of medical cannabis shipped,” said Brent Zettl, co-founder and Chief Executive Officer of CMED. “With our strong growth trajectory, we are continually analyzing the market demand and utilizing our facilities effectively to ensure a consistent supply of medical cannabis products available for our patients.”

CMED is the first Licensed Producer inspected for Health Canada’s Good Manufacturing Practices (GMP) standard in Canada and has been “Compliant” with the Food and Drug Act - Part C, Division 2 and its associated Regulations for the testing and distribution of dried marihuana since 2006. CMED quality systems compliance is achieved by following rigorous standard operating procedures at all stages of manufacturing and affords the Company the ability to effectively and efficiently plan for market changes and increases in volume.

In CMED’s 15 year tenure following GMP standards, including extensive quality control processes, the Company has never been unable to fulfil a patient order and has never had a product recall.

The Company plans to release its financial results for the fiscal year end of October 31, 2016 on February 23, 2017.

The Company has not prepared any financial statements for the fiscal quarter ended January 31, 2017. Accordingly, it has not determined its revenue, gross margin, expenses, (loss) or income from operations, or (loss) or income for the period. Notwithstanding the record sales volumes, the Company has not determined whether its results of operations for the quarter will show an improvement over prior periods. The Company expects to release its financial statements for the quarter ended January 31, 2017 by March 17, 2017 on a date to be determined.

About CanniMed Therapeutics Inc.

The Company is a Canadian-based, international plant biopharmaceutical company and a leader in the Canadian medical cannabis industry, with 15 years of pharmaceutical cannabis cultivation experience, state-of-the-art, GMP-compliant production process and world class research and development platforms with a wide range of pharmaceutical-grade cannabis products. In addition, the Company has an active plant biotechnology research and product development program focused on the production of plant-based materials for pharmaceutical, agricultural and environmental applications.

CanniMed Ltd., a wholly-owned subsidiary of the Company, was the first producer to be licensed under the Marihuana for Medical Purposes Regulations, the predecessor to the current Access to Cannabis for Medical Purposes Regulations.

Prairie Plant Systems Inc., a wholly-owned subsidiary of the Company, was the sole supplier to Health Canada under the former medical marijuana system for 13 years, and has been producing safe and consistent medical marijuana for thousands of Canadian patients, with no incident of diversion.

Notice Regarding Forward Looking Statements

This news release contains forward-looking statements within the meaning of applicable securities laws. All statements that are not historical facts, including without limitation, statements regarding future estimates, plans, programs, forecasts, projections, objectives, assumptions, expectations or beliefs of future performance and the expected release date for its financial results, are “forward-looking statements”. Forward-looking statements can be identified by the use of words such as “plans”, “expects” or “does not expect”, “is expected”, “estimates”, “intends”, “anticipates” or “does not anticipate”, or “believes”, or variations of such words and phrases or state that certain actions, events or results “may”, “could”, “would”, “might” or “will” be taken, occur or be achieved.

Forward-looking statements are based on assumptions and involve known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of CanniMed Therapeutics Inc. to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements, including the risk that the results of operations for the year ended October 31, 2015 and the quarter ended January 31, 2017 will not show an improvement over comparable periods in the prior year and may be delayed and the risks described in CanniMed Therapeutics Inc.’s documents filed with applicable Canadian securities regulatory authorities which may be viewed at sedar.com. The forward-looking statements included in this news release are made as of the date of this news release. CanniMed Therapeutics Inc. does not undertake to publicly update such forward-looking statements to reflect new information, subsequent events or otherwise, unless required by applicable securities legislation.

For more information, please contact:

Dara Willis
CanniMed Therapeutics Inc.
(416) 836-9272
media@cannimed.com

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University of Saskatchewan launches study of cannabis treatment for childhood epilepsy

Saskatoon, Saskatchewan [February 1, 2017] — The Pediatrics Department at the University of Saskatchewan (U of S) is launching a study examining the use of Cannabidiol (CBD) to treat children with medically intractable epilepsy and associated cognitive decline, after recently obtaining Health Canada approval to proceed.

The main goal of the study is to determine if high concentrated CBD oil can be used safely in children with epilepsy. Researchers also hope to determine optimal dosing and CBD oil’s impact on seizure control and quality of life.

Dr. Richard Huntsman, pediatric neurologist at the U of S, and Dr. Richard Tang-Wai, pediatric epileptologist, University of Alberta, will lead a multidisciplinary research group through a collaborative approach to expand knowledge of medical cannabis for use in human and veterinary applications. Supplying the CBD for the study is CanniMed Therapeutics Inc. of Saskatoon, a company with an extensive history of collaborative research with the U of S and the most experience in producing medical cannabis products in Canada.

Thirty children between the ages of one to 10 years will be recruited from sites across Canada, including the U of S, U of A, University of British Columbia, McGill University and Université de Montréal. The study will bring together a large group of experts in pediatric neurology, pharmacology, pharmacy, clinical biochemical analysis, psychology and biostatistics.

“Many of these children have adverse reactions to any of the treatments that we offer and they suffer significant side effects from them,” Huntsman said. “I believe we owe it to these children and their families to look at all potential treatment options, including cannabis-based products, if they can offer any hope of helping.”

He added that the parents he sees in clinic are often desperate for any treatment that can help their children.

“Parents are becoming more aware of the use of cannabis to treat epilepsy from social media and parent support groups,” said Tang-Wai. “Because there is little scientific evidence regarding the use of cannabis products in children, most physicians are reluctant to prescribe them, resulting in parents trying to make their own preparations at home or turning to suppliers who cannot verify the quality of their product. This adds to the urgency of doing studies like this.”

The study is financed entirely through support from the Children’s Hospital Foundation of Saskatchewan, the Durwood Seafoot Estate, the Saskatchewan Health Research Foundation and the Savoy Foundation. External funding was important to the research group, which wanted to avoid any potential perceptions of bias or conflict of interest.

“This truly is a remarkable and exciting new opportunity for Canadian children and the research that is required to help them live happier and healthier lives,” said Brynn Boback-Lane, president and CEO of the Children’s Hospital Foundation of Saskatchewan. “Pediatric research is critical in the creation of improved treatments and lasting impact on children and their healthcare. We’re very pleased to support this important project that gives hope to so many, not only in Saskatchewan but right across the country. In fact, this is the kind of research that Saskatchewan can share throughout the world.”

“The research team that has been brought together for this research study is an important example of collaborative work that can be done at the University of Saskatchewan,” said Dr. Laurence Givelichian, head of the Department of Pediatrics.

This study has helped to launch the newly formed Cannabinoid Research Initiative of Saskatchewan, a research group including Drs. Huntsman and Tang-Wai, as well as Andrew Lyon, Darrell Mousseau, Blair Seifert and Jane Alcorn from the Colleges of Medicine, Pharmacy and Nutrition, as well as Veterinary Medicine. Through a collaborative research approach, this multidisciplinary group hopes to expand our knowledge of medical cannabis for use in human and veterinary applications.

The research team hopes to begin recruiting patients at the U of S site within the next two months.

For more information, or to arrange an interview with Dr. Huntsman or Dr. Tang-Wai, contact:

Kate Blau
Communications Specialist
College of Medicine
University of Saskatchewan
306-966-6059
kate.blau@usask.ca


Administrative - Required messages.
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CANNIMED THERAPEUTICS INC.

CanniMed Therapeutics Inc. Closes Over-Allotment

NOT FOR DISTRIBUTION TO U.S. NEWS WIRE SERVICES OR DISSEMINATION IN THE UNITED STATES.

Saskatoon, Saskatchewan [January 30, 2017] — CanniMed Therapeutics Inc. (TSX:CMED) (“CMED” or the “Company”), a leading plant biopharmaceutical company specializing in the production of pharmaceutical-grade cannabis, announced today that the underwriters for CMED’s initial public offering (the “Offering”) have exercised their over-allotment option (the “Over-Allotment Option”) to purchase an additional 750,000 common shares of CMED at a price of $12.00 per common share (the “Optional Shares”). The sale of the Optional Shares increases the gross proceeds of the Offering by $9,000,000, resulting in aggregate gross proceeds to CMED of $69,000,000.

The Offering was made through a syndicate of underwriters led by AltaCorp Capital Inc. and including Canaccord Genuity Corp., Clarus Securities Inc., Mackie Research Capital Corporation and Haywood Securities Inc.

No securities regulatory authority has either approved or disapproved of the contents of this news release. The common shares have not been, nor will they be, registered under the United States Securities Act of 1933, as amended, or any state securities laws, and may not be offered or sold in the United States, or to or for the account or benefit of any person in the United States, absent registration or an applicable exemption from the registration requirements. This press release shall not constitute an offer to sell or the solicitation of an offer to buy any common shares in the United States, or in any other jurisdiction in which such offer, solicitation or sale would be unlawful.

About CanniMed Therapeutics Inc.

The Company is a Canadian-based, international plant biopharmaceutical company and a leader in the Canadian medical cannabis industry, with 15 years of pharmaceutical cannabis cultivation experience, state-of-the-art, GMP-compliant production process, including 281 points of quality control, and world class research and development platforms with a wide range of pharmaceutical-grade cannabis products. In addition, the Company has an active plant biotechnology research and product development program focused on the production of plant-based materials for pharmaceutical, agricultural and environmental applications.

CanniMed Ltd., a wholly-owned subsidiary of the Company, was the first producer to be licensed under the Marihuana for Medical Purposes Regulations, the predecessor to the current Access to Cannabis for Medical Purposes Regulations.

Prairie Plant Systems Inc., a wholly-owned subsidiary of the Company, was the sole supplier to Health Canada under the former medical marijuana system for 13 years, and has been producing safe and consistent medical marijuana for thousands of Canadian patients, with no incident of diversion.

Forward Looking Statement

This press release contains “forward-looking information” within the meaning of Canadian securities laws, which may include, but are not limited to statements relating to the future growth of the Company’s business. Such forward-looking information reflects the Company’s views with respect to future events and is subject to risks, uncertainties and assumptions, including those set out in the final prospectus dated December 21, 2016 and the risk that the Company’s expected growth will not be achieved. The Company does not undertake to update forward-looking statements or forward-looking information, except as required by law.

For more information, please contact:

Dara Willis
CanniMed Therapeutics Inc.
(416) 836-9272
media@cannimed.com

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CANNIMED THERAPEUTICS INC.

CANNIMED COMPLETES INITIAL PUBLIC OFFERING

NOT FOR DISTRIBUTION TO U.S. NEWS WIRE SERVICES OR DISSEMINATION IN THE UNITED STATES.

Saskatoon, Saskatchewan [December 29, 2016] — CanniMed Therapeutics Inc. (“CMED” or the “Company”), a leading plant biopharmaceutical company specializing in the production of pharmaceutical-grade cannabis, announced today that it has successfully completed an initial public offering of its common shares (the “Offering”). In connection with the Offering, CMED issued 5,000,000 common shares at a price of $12.00 per common share, resulting in aggregate gross proceeds to CMED of $60,000,000. CMED’s common shares will begin trading today on the Toronto Stock Exchange under the symbol “CMED”.

“CanniMed’s IPO represents a major milestone for the company and provides us with additional capital to support our continued growth, both in Canada and internationally,” said Brent Zettl, co-founder and Chief Executive Officer of CMED. “We believe we are at the early stages of a tremendous growth opportunity for medical cannabis, and CanniMed is focused on becoming the supplier of choice in the medical community and with patients who are looking for consistent, high-quality treatment alternatives in delivery forms that align to traditional methods.”

The Offering was made through a syndicate of underwriters led by AltaCorp Capital Inc. and including Canaccord Genuity Corp., Clarus Securities Inc., Mackie Research Capital Corporation and Haywood Securities Inc. CMED has granted the underwriters an over-allotment option, exercisable in whole or in part, for a period of 30 days following the closing of the Offering, to purchase up to an additional 750,000 common shares at $12.00 per common share

Borden Ladner Gervais LLP acted as counsel to CMED and Stikeman Elliott LLP acted as counsel to the underwriters.

No securities regulatory authority has either approved or disapproved of the contents of this news release. The common shares have not been, nor will they be, registered under the United States Securities Act of 1933, as amended, or any state securities laws, and may not be offered or sold in the United States, or to or for the account or benefit of any person in the United States, absent registration or an applicable exemption from the registration requirements. This press release shall not constitute an offer to sell or the solicitation of an offer to buy any common shares in the United States, or in any other jurisdiction in which such offer, solicitation or sale would be unlawful.

About CanniMed Therapeutics Inc.

The Company is a Canadian-based, international plant biopharmaceutical company and a leader in the Canadian medical cannabis industry, with 15 years of pharmaceutical cannabis cultivation experience, state-of-the-art, GMP-compliant plant production processes, including 281 points of quality control, and world class research and development platforms with a wide range of pharmaceutical-grade cannabis products. In addition, the Company has an active plant biotechnology research and product development program focused on the production of plant-based materials for pharmaceutical, agricultural and environmental applications.

CanniMed Ltd., a wholly-owned subsidiary of the Company, was the first producer to be licensed under the Marihuana for Medical Purposes Regulations, the predecessor to the current Access to Cannabis for Medical Purposes Regulations.

Prairie Plant Systems Inc., a wholly-owned subsidiary of the Company, was the sole supplier to Health Canada under the former medical marijuana system for 13 years, and has been producing safe and consistent medical marijuana for thousands of Canadian patients, with no incident of diversion.

Forward Looking Statement

This press release contains “forward-looking information” within the meaning of Canadian securities laws, which may include, but are not limited to statements relating to the Company’s proposed initial public offering and expectations that applicable regulatory approvals will be obtained. Such forward-looking information reflects the Company’s views with respect to future events and is subject to risks, uncertainties and assumptions, including those set out in the amended and restated preliminary prospectus dated December 6, 2016 and the risk that the Offering may not be completed. The Company does not undertake to update forward-looking statements or forward-looking information, except as required by law.

For more information, please contact:

Dara Willis
CanniMed Therapeutics Inc.
(416) 836-9272
media@cannimed.com

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CANNIMED THERAPEUTICS INC.

CANNIMED FILES FINAL PROSPECTUS AND ANNOUNCES PRICING FOR INITIAL PUBLIC OFFERING

NOT FOR DISTRIBUTION TO U.S. NEWS WIRE SERVICES OR DISSEMINATION IN THE UNITED STATES.

Saskatoon, Saskatchewan [December 21] - CanniMed Therapeutics Inc. (“CMED” or the “Company”), a leading plant biopharmaceutical company specializing in the production of pharmaceutical-grade cannabis, announced today the pricing of its initial public offering of 5,000,000 common shares at a price of $12.00 per common share (the “Offering”). The Offering is expected to result in aggregate gross proceeds to CMED of $60,000,000. In addition, CMED has granted the underwriters an option, exercisable in whole or in part for a period of 30 days following the closing of the Offering, to purchase up to an additional 750,000 common shares at a price of $12.00 per common share, to cover over-allotments, if any (the “Over-Allotment Option").

Closing of the Offering is expected to take place on or about December 29, 2016, subject to customary closing conditions, at which time the common shares will commence trading on the Toronto Stock Exchange (the “TSX”) under the symbol “CMED”. CMED has received conditional approval for the listing of its common shares on the TSX, subject to CMED fulfilling all of the customary requirements of the TSX.

The Offering is being made through a syndicate of underwriters led by AltaCorp Capital Inc. and including Canaccord Genuity Corp., Clarus Securities Inc., Mackie Research Capital Corporation and Haywood Securities Inc.

A copy of the final prospectus is available on SEDAR (www.sedar.com).

No securities regulatory authority has either approved or disapproved of the contents of this news release. The common shares have not been, nor will they be, registered under the United States Securities Act of 1933, as amended, or any state securities laws, and may not be offered or sold in the United States, or to or for the account or benefit of any person in the United States, absent registration or an applicable exemption from the registration requirements. This press release shall not constitute an offer to sell or the solicitation of an offer to buy any common shares in the United States, or in any other jurisdiction in which such offer, solicitation or sale would be unlawful.

About CanniMed Therapeutics Inc.

The Company is a Canadian-based, international plant biopharmaceutical company and a leader in the Canadian medical cannabis industry, with 15 years of pharmaceutical cannabis cultivation experience, state-of-the-art, GMP-compliant production process, including 281 points of quality control, and world class research and development platforms with a wide range of pharmaceutical-grade cannabis products. In addition, the Company has an active plant biotechnology research and product development program focused on the production of plant-based materials for pharmaceutical, agricultural and environmental applications.

CanniMed Ltd., a wholly-owned subsidiary of the Company, was the first producer to be licensed under the Marihuana for Medical Purposes Regulations, the predecessor to the current Access to Cannabis for Medical Purposes Regulations.

Prairie Plant Systems Inc., a wholly-owned subsidiary of the Company, was the sole supplier to Health Canada under the former medical marijuana system for 13 years, and has been producing safe and consistent medical marijuana for thousands of Canadian patients, with no incident of diversion.

Forward Looking Statement

This press release contains “forward-looking information” within the meaning of Canadian securities laws, which may include, but are not limited to statements relating to the trading date of the Company’s common shares and the exercise by the underwriters of the over-allotment option. Such forward-looking information reflects the Company’s views with respect to future events and is subject to risks, uncertainties and assumptions, including those set out in the final prospectus dated December 21, 2016, the risk that closing of the Offering will be delayed and the risk that the Offering may not be completed. The Company does not undertake to update forward-looking statements or forward-looking information, except as required by law.

For more information, please contact:

Dara Willis
CanniMed Therapeutics Inc.
(416) 836-9272
media@cannimed.com

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CANNIMED THERAPEUTICS INC.

CANNIMED THERAPEUTICS INC. ANNOUNCES FILING OF AMENDED AND RESTATED PRELIMINARY PROSPECTUS

NOT FOR DISTRIBUTION TO U.S. NEWS WIRE SERVICES OR DISSEMINATION IN THE UNITED STATES.

Saskatoon, Saskatchewan [December 6] - CanniMed Therapeutics Inc. (“CMED” or the “Company”), a leading plant biopharmaceutical company specializing in the production of pharmaceutical-grade cannabis, announced today that it has filed an amended and restated preliminary prospectus in respect of its initial public offering of common shares (“Common Shares”) with the securities regulatory authorities in each of the provinces of Canada, except Quebec (the “Offering”), which amends and restates the preliminary prospectus dated November 23, 2016. The amended and restated preliminary prospectus states that the Company proposes to sell Common Shares for aggregate gross proceeds to the Company of approximately C$50,000,000. The Offering is being distributed by a syndicate of underwriters led by AltaCorp Capital Inc. and including Canaccord Genuity Corp., Clarus Securities Inc., Mackie Research Capital Corporation and Haywood Securities Inc. A copy of the amended and restated preliminary prospectus is available on SEDAR (www.sedar.com).

Completion of the Offering is subject to, and conditional upon, the receipt of all necessary approvals, including regulatory approvals.

The amended and restated preliminary prospectus has not yet become final for the purposes of the sale of the securities and information contained in the amended and restated preliminary prospectus may not be complete and may have to be amended. There will not be any sale or any acceptance of an offer to buy the securities until a receipt for the final prospectus has been issued.

No securities regulatory authority has either approved or disapproved of the contents of this news release. The Common Shares have not been, nor will they be, registered under the United States Securities Act of 1933, as amended, or any state securities laws, and may not be offered or sold in the United States, or to or for the account or benefit of any person in the United States, absent registration or an applicable exemption from the registration requirements. This press release shall not constitute an offer to sell or the solicitation of an offer to buy any Common Shares in the United States, or in any other jurisdiction in which such offer, solicitation or sale would be unlawful.

About CanniMed Therapeutics Inc.

The Company is a Canadian-based, international plant biopharmaceutical company and a leader in the Canadian medical cannabis industry, with 15 years’ of pharmaceutical cannabis cultivation experience, state-of-the-art, GMP-compliant production process, including 281 points of quality control, and world class research and development platforms with a wide range of pharmaceutical-grade cannabis products. In addition, the Company has an active plant biotechnology research and product development program focused on the production of plant-based materials for pharmaceutical, agricultural and environmental applications.

CanniMed Ltd., a wholly-owned subsidiary of the Company, was the first producer to be licensed under the Marihuana for Medical Purposes Regulations, the predecessor to the current Access to Cannabis for Medical Purposes Regulations.

Prairie Plant Systems Inc., a wholly-owned subsidiary of the Company, was the sole supplier to Health Canada under the former medical marijuana system for 13 years, and has been producing safe and consistent medical marijuana for thousands of Canadian patients, with no incident of diversion.

Forward Looking Statement

This press release contains “forward-looking information” within the meaning of Canadian securities laws, which may include, but are not limited to statements relating to the Company’s proposed initial public offering and expectations that applicable regulatory approvals will be obtained. Such forward-looking information reflects the Company’s views with respect to future events and is subject to risks, uncertainties and assumptions, including those set out in the amended and restated preliminary prospectus dated December 6, 2016 and the risk that the Offering may not be completed. The Company does not undertake to update forward-looking statements or forward-looking information, except as required by law.

For more information, please contact:

Dara Willis
CanniMed Therapeutics Inc.
(416) 836-9272
media@cannimed.com

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CANNIMED THERAPEUTICS INC.

CANNIMED THERAPEUTICS INC. ANNOUNCES FILING OF PRELIMINARY PROSPECTUS

NOT FOR DISTRIBUTION TO U.S. NEWS WIRE SERVICES OR DISSEMINATION IN THE UNITED STATES.

Saskatoon, Saskatchewan [November 28] - CanniMed Therapeutics Inc. (“CMED” or the “Company”), a leading plant biopharmaceutical company specializing in the production of pharmaceutical-grade cannabis, announced today that it has filed a preliminary prospectus with the securities regulatory authorities in each of the provinces of Canada, except Quebec, in connection with a proposed initial public offering (the “Offering”) of its common shares (“Common Shares”). A copy of the preliminary prospectus is available on SEDAR (www.sedar.com).

The Offering will be made through a syndicate of underwriters led by AltaCorp Capital Inc.

The preliminary prospectus has not yet become final for the purposes of the sale of the securities, and information contained in the preliminary prospectus may not be complete and may have to be amended. There will not be any sale or any acceptance of an offer to buy the securities until a receipt for the final prospectus has been issued.

No securities regulatory authority has either approved or disapproved of the contents of this news release. The Common Shares have not been, nor will they be, registered under the United States Securities Act of 1933, as amended, or any state securities laws, and may not be offered or sold in the United States, or to or for the account or benefit of any person in the United States, absent registration or an applicable exemption from the registration requirements. This press release shall not constitute an offer to sell or the solicitation of an offer to buy any Common Shares in the United States, or in any other jurisdiction in which such offer, solicitation or sale would be unlawful.

About CanniMed Therapeutics Inc.

The Company is a Canadian-based, international plant biopharmaceutical company and a leader in the Canadian medical cannabis industry, with 15 years’ of pharmaceutical cannabis cultivation experience, state-of-the-art, GMP-compliant production process, including 281 points of quality control, and world class research and development platforms with a wide range of pharmaceutical-grade cannabis products. In addition, the Company has an active plant biotechnology research and product development program focused on the production of plant-based materials for pharmaceutical, agricultural and environmental applications.

CanniMed Ltd., a wholly-owned subsidiary of the Company, was the first producer to be licensed under the Marihuana for Medical Purposes Regulations, the predecessor to the current Access to Cannabis for Medical Purposes Regulations.

Prairie Plant Systems Inc., a wholly-owned subsidiary of the Company, was the sole supplier to Health Canada under the former medical marijuana system for 13 years, and has been producing safe and consistent medical marijuana for thousands of Canadian patients, with no incident of diversion.

Forward Looking Statement

This press release contains “forward looking information” within the meaning of Canadian securities laws, which may include, but are not limited to statements relating to the Company’s proposed initial public offering and that the Offering will be made by a syndicate of underwriters. Such forward-looking information reflects the Company’s views with respect to future events and is subject to risks, uncertainties and assumptions, including those set out in the preliminary prospectus dated November 23, 2016 and the risk that the Offering may not be completed. The Company does not undertake to update forward looking statements or forward looking information, except as required by law.

For more information, please contact:

Dara Willis
CanniMed Therapeutics Inc.
(416) 836-9272
media@cannimed.com

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CTT Pharmaceutical Holdings to License to CanniMed Ltd. Novel Cannabis Orally Dissolvable Thin Film (ODF) Wafer Drug Delivery Technology for North American Markets

Saskatoon, SK

CanniMed Ltd. CTT Pharma

Ottawa/SASKATOON, Aug. 11, 2016 -CanniMed Ltd. has entered into a letter of intent with CTT Pharmaceutical Holdings Inc. (OTCQB:CTTH) to license CTT’s Orally Dissolvable Thin Film (ODF) Wafer technology. This industry-first collaboration will enable CanniMed Ltd. to develop and commercialize this novel, smoke-free, drug delivery system in both Canada and the United States.

Orally Dissolvable Thin Film (ODF) Wafers are paper-thin polymer films used as carriers for several pharmaceutical agents, including opioids for pain management. In this innovative format, the drug is taken orally but does not require water or swallowing. ODF Wafers dissolve quickly in the oral cavity (5-15 seconds) ensuring that the active ingredient is rapidly absorbed and diffused into the dense network of capillaries for direct access to the bloodstream via the oral mucosa. The active ingredient, once absorbed, bypasses the liver’s first-pass effect and effectively improves bioavailability and facilitates excellent patient compliance.

“Our novel and breakthrough technology will provide a more convenient, smoke-free, effective and healthier drug delivery system allowing patients to take precise and accurate doses of cannabinoids as prescribed for pain management, mental disorders like depression, anxiety, post-traumatic stress disorder and a reduction in epileptic seizure syndromes in children,” said Dr. Pankaj Modi, President and CEO, CTT Pharmaceutical Holdings. “We sought out this collaboration with CanniMed as a result of their industry-leading cultivation and extraction processes.”

Orally Dissolvable Thin Film Wafers improve therapeutic outcome and efficacy through immediate onset of action in a convenient and discrete delivery. ODF Wafers are suitable for geriatric and pediatric patients who experience difficulty swallowing or patients who suffer from Phagophobia (fear of swallowing) or Pnigophobia (fear of choking).

“Physicians and patients are looking for novel and effective drug delivery systems to help with their consumption of medical cannabis, and this ODF Wafer system will complement the already well-integrated line of CanniMed® Oil products we have in market,” said Brent Zettl, CEO CanniMed Ltd. “Standardizing and supporting patients with dose-sensitive and discrete delivery systems will continue to position medical cannabis as an important therapeutic option for thousands of patients in Canada and the United States.”

About CTT Pharmaceutical Holdings

CTT’s principal asset is a unique and novel patented drug delivery technology, an orally administered, fast dissolving thin film (the “Wafer”). This technology platform will target both the human and veterinarian (pet) markets for treatment of many diseases including pain management.

The Oral Thin Film (Wafer) formulation is protected by several Canadian and US Patents. CTT’s oral fast dissolving drug delivery systems will consist of edible thin films (wafers) that dissolve without water, within a few seconds after placement in the mouth. The majority of drugs administered using our drug delivery system mirror injections in that they have the ability to enter the bloodstream quickly, are convenient and discrete, and can be administered anywhere. A faster absorption rate is achieved because the mouth contains a very thin mucosa and is extremely vascular. There is no bitter taste, no smoke inhalation as is the case with cannabis, and less degradation of medication (by bypassing the stomach) and most importantly lower dosage units are required given the efficacy of absorption. Patient compliance is improved, especially with those who have a fear of choking and/or are pediatric, geriatric or incapacitated patients who have difficulty swallowing.

Most fast dissolving systems on the market today deliver anti-inflammatories, antihistamines and cough and breathing related medications. CTT believes that its Wafer technology will be one of the first to gain use in major markets such as pain management.

For more information, please visit our website: www.cttpharmaceuticals.com

About CanniMed Ltd.

CanniMed Ltd. was the first producer to be licensed under the Marihuana for Medical Purposes Regulations (MMPR) and has the longest growing history as a result of the parent company, Prairie Plant Systems Inc., being the sole supplier for the entirety of Health Canada’s former medical marijuana program.

Prairie Plant Systems, the cultivation arm of the company, follows Good Manufacturing Practices (GMP) regulations, the criteria used to manufacture all pharmaceuticals in Canada. This industry-leading production excellence, including a 281-point quality control process, ensures product consistency and patient safety.

The company has a strong corporate priority to design and execute clinical research that will close the gap between the anecdotal benefit and evidence based medicine in order to standardize care. Prairie Plant Systems is the only Licensed Producer whose cannabis has already been used in two published clinical trials.

A randomized, controlled trial of smoked cannabis for chronic neuropathic pain - this study found that a single inhalation of 25 mg of 9.4% THC herbal cannabis three times daily for five days reduced the intensity of pain, improved sleep quality, reduced anxiety and was well tolerated.i

The results of this study were used in the development of the Canadian Pain Society’s Pharmacological management of chronic neuropathic pain: Revised consensus statement positioning medical cannabis as third line treatment for neuropathic pain.ii

A randomized controlled trial of herbal cannabis on chronic non-cancer pain - this was the first and largest study looking at the long term safety of medical cannabis use by patients suffering from chronic pain. Patients were given access to herbal cannabis containing 12.5% THC (CanniMed 12.0) and were followed over one year. The researchers found that patients with chronic pain, who used cannabis daily for one year, when carefully monitored, did not have an increase in serious adverse events compared to pain patients who did not use cannabis. This study was published in the Journal of Pain.iii

Patient recruitment has begun on the Health Canada approved CAPRI Trial (Cannabinoid Profile Investigation of Vaporized Cannabis in Patients with Osteoarthritis of the Knee), a randomized, double blind, placebo controlled, proof-of-concept, crossover clinical trial of single dose vaporized cannabis in adults with painful osteoarthritis of the knee.

For more information, please visit our website: www.cannimed.ca

Agreement Terms

Upon execution of the Letter of Intent, CTT was paid $25,000USD. Upon execution of the Licensing Agreement CTT will be paid $40,000USD and will receive a royalty of 5 per cent based on gross sales. Additional payments will be made to CTT upon reaching certain milestones to be negotiated between the parties. The parties will use their best efforts to execute a Licensing Agreement by September 30, 2016. However, there can be no assurance that the parties will come to terms on a definitive agreement.

Forward Looking Statements

This press release contains forward-looking statements, which can be identified by the use of statements that include words such as "could", "potential", "believe", "expect", "anticipate", "intend", "plan", "likely", "will" or other similar words or phrases. These statements are only current predictions and are subject to known and unknown risks, uncertainties and other factors that may cause our or our industry's actual results, levels of activity, performance or achievements to be materially different from those anticipated by the forward-looking statements. The Company does not intend, and does not assume any obligation, to update forward-looking statements, whether as a result of new information, future events or otherwise, unless otherwise required by applicable securities laws. Readers should not place undue reliance on forward-looking statements.

For more information or to schedule an interview, please contact:

Dara Willis
Dara Willis Communications
Mobile: 416-836-9272
Email: dara@dwcomm.ca


i Ware, M.A., Wang, T., Shapiro, S., Robinson, A. and others. (2010) Smoked Cannabis for Chronic Pain: a Randomized Controlled Trial. Canadian Medical Association Journal (CMAJ). 182:E694-E701.

ii Moulin, D.E., Boulanger, A., Clark A.J., Dao, T. and others. (2014) Pharmacological Management of Chronic Neuropathic Pain: Revised Consensus Statement from the Canadian Pain Society. Pain Research and Management. Nov-Dec; 19(6): 328–335.

iii Ware, M.A., Wang, T., Shapiro, S. and others. (2015) Cannabis for the Management of Pain: Assessment of Safety Study (COMPASS). The Journal of Pain. Vol 16. Nov 12. http://www.jpain.org/article/S1526-5900(15)00837-8/pdf

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Prairie Plant Systems and CanniMed Granted Section 56 Exemptions to Begin Cannabis Oils Production

Saskatoon, SK

Prairie Plant Systems Inc. and CanniMed Ltd. have successfully received Section 56 exemptions under the Marihuana for Medical Purposes Regulations (MMPR) governed by Health Canada and as a result have begun oil manufacturing for patients.

Similar to the seven dry cannabis products currently being offered, CanniMed® oils will be available in three distinct THC-to-CBD ratios:

  • CanniMed® oil 18:0 – containing 18.3 mg/ml THC and 0.2 mg/ml CBD
  • CanniMed® oil 10:10 – containing 9.7 mg/ml THC and 10.3 mg/ml CBD
  • CanniMed® oil 1:20 – containing 1.2 mg/ml THC and 20.5 mg/ml CBD

“We are very proud to be among the first licensed producers to receive the go ahead from Health Canada to manufacture CanniMed oils for our patients,” said Brent Zettl, President and CEO of Prairie Plant Systems Inc. and CanniMed Ltd. “Patient requests for oils have been significant with as many as 67 per cent responding to an informal survey suggesting they would prefer this delivery method over smoking or vaporizing.”

CanniMed® oil will be packaged in 60 ml bottles and include an oral syringe for consistent dosing and as a spill prevention.

About CanniMed and Prairie Plant Systems

CanniMed Ltd. was the first producer to be licensed under the new Marihuana for Medical Purposes Regulations (MMPR). Our pharmaceutical-grade marijuana is produced under Good Manufacturing Practices (GMP) regulations, the criteria used to manufacture all pharmaceuticals in Canada. Our primary focus is on patient safety, undertaken by strictly following a 281 point quality control process.

CanniMed's parent company, Prairie Plant Systems Inc. was the sole supplier to Health Canada under the former medical marijuana system for 13 years, and has been producing safe and consistent medical marijuana for thousands of Canadian patients, with no incident of diversion.

These two companies together have created the leading medical cannabis company in Canada with a strong corporate priority to design and execute clinical research that will close the gap between the anecdotal benefit and evidence based medicine in order to standardize care. Our Canadian-grown cannabis is already leading the way in standardizing care and has been used in a published clinical trial demonstrating the efficacy of smoked cannabis for chronic pain,i which was used in the development of the Canadian Pain Society's Pharmacological management of chronic neuropathic pain: Revised consensus statement positioning medical cannabis as third line treatment for neuropathic pain.ii

_______________

i Ware, M.A., Wang, T., Shapiro, S., Robinson, A. and others. (2010) Smoked Cannabis for Chronic Pain: a Randomized Controlled Trial. Canadian Medical Association Journal (CMAJ). 182:E694-E701.

ii Moulin, D.E., Boulanger, A., Clark A.J., Dao, T. and others. (2014) Pharmacological Management of Chronic Neuropathic Pain: Revised Consensus Statement from the Canadian Pain Society. Pain Research and Management. Nov-Dec; 19(6): 328–335.

For further information:

CanniMed Ltd.
Phone: 1-855-787-1577
Email: info@cannimed.com

Dara Willis
Dara Willis Communications
Mobile: 416-836-9272
Email: dara@dwcomm.ca

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First Health Canada Approved Medical Cannabis Clinical Trial Starts Patient Recruitment

Landmark trial will be first to study safety and efficacy of a series of cannabinoid profiles

Saskatoon, SK

Prairie Plant Systems and CanniMed, Canada's most well-established and reliable producer of medical cannabis, along with researchers at McGill University Health Centre and Dalhousie Universities, officially start patient engagement today on the CAPRI Trial (Cannabinoid Profile Investigation of Vaporized Cannabis in Patients with Osteoarthritis of the Knee), a randomized, double blind, placebo controlled, proof-of-concept, crossover clinical trial of single dose vaporized cannabis in adults with painful osteoarthritis of the knee.

Not only was this clinical trial the first to be registered with Health Canada after the transition to the new Marihuana for Medical Purposes Regulations (MMPR), CAPRI will seek to understand the analgesic dose-response of several varieties of medical cannabis, consisting of varying concentrations of the two most common active ingredients: delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). It will also explore the short-term safety of vaporized cannabis as well as look at functional changes and patient preference.

"Anecdotal evidence supporting cannabis as a medicine is increasing, however this isn't quite good enough for our patients," said Brent Zettl, President and CEO of Prairie Plant Systems Inc. and CanniMed Ltd. "In order for medical cannabis to become a true medicine, it requires carefully conducted trials to provide hard data. It is our ongoing mission to support patients and their prescribing physicians with more research into the safety and efficacy of these cannabis based products to ensure predictable and standardized treatment options in the near future."

The CAPRI Trial will be recruiting 40 patients suffering from serious osteoarthritis of the knee over the two trial sites in Montreal, QC and Halifax, NS. Patient recruitment starts today at the McGill University Health Centre, and Dalhousie University will begin to recruit patients shortly.

"This clinical trial significantly advances medical cannabis research in Canada," said Dr. Mark Ware, CAPRI trial primary investigator and practicing pain physician at the McGill University Health Centre, and Executive Director of the Canadian Consortium for the Investigation of Cannabinoids (CCIC). "This research will help to start answering important questions physicians have regarding dosing as well as short term safety and efficacy related to specific ratios of cannabinoids."

The body's own pain-regulating system, called the endocannabinoid system, has receptors in nervous system tissue, immune cells, bone and joint tissue. These receptors respond to the cannabinoids found in medical cannabis, similar to how a key opens a lock. Research has demonstrated the short term efficacy of medical cannabis at reducing pain when used by itself or in combination with other pain-relievers, but comparisons between cannabinoid ratios have not been tested in clinical settings.

For the 4.6 million Canadians with arthritis, currently available medications are often inadequate or associated with unacceptable side effects. Research into new treatment options, including the potential therapeutic benefit of medical cannabis, is an important next step in determining options available to patients and their caregivers.

"We are very pleased to see that the CAPRI clinical trial is underway and beginning recruitment," said Joanne Simons, chief mission officer, The Arthritis Society. "We know that many people living with arthritis seek alternative options for pain relief, including medical cannabis. Well-designed clinical research is a pre-requisite to get us to where we want to go: more treatment options available to help people manage the pain of arthritis."

About CanniMed and Prairie Plant Systems

CanniMed Ltd. was the first producer to be licensed under the new Marihuana for Medical Purposes Regulations (MMPR). Our pharmaceutical-grade marijuana is produced under Good Manufacturing Practices (GMP) regulations, the criteria used to manufacture all pharmaceuticals in Canada. Our primary focus is on patient safety, undertaken by strictly following a 281 point quality control process.

CanniMed's parent company, Prairie Plant Systems Inc. was the sole supplier to Health Canada under the former medical marijuana system for 13 years, and has been producing safe and consistent medical marijuana for thousands of Canadian patients, with no incident of diversion.

These two companies together have created the leading medical cannabis company in Canada with a strong corporate priority to design and execute clinical research that will close the gap between the anecdotal benefit and evidence based medicine in order to standardize care. Our Canadian-grown cannabis is already leading the way in standardizing care and has been used in a published clinical trial demonstrating the efficacy of smoked cannabis for chronic pain,i which was used in the development of the Canadian Pain Society's Pharmacological management of chronic neuropathic pain: Revised consensus statement positioning medical cannabis as third line treatment for neuropathic pain.ii

___________________________________________
i Ware, M.A., Wang, T., Shapiro, S., Robinson, A. and others. (2010) Smoked Cannabis for Chronic Pain: a Randomized Controlled Trial. Canadian Medical Association Journal (CMAJ). 182:E694-E701.
ii Moulin, D.E., Boulanger, A., Clark A.J., Dao, T. and others. (2014) Pharmacological Management of Chronic Neuropathic Pain: Revised Consensus Statement from the Canadian Pain Society. Pain Research and Management. Nov-Dec; 19(6): 328-335.

SOURCE Prairie Plant Systems Inc.

For further information:

CanniMed Ltd.
Phone: 1-855-787-1577
Email: info@cannimed.com

Dara Willis
Dara Willis Communications
Mobile: 416-836-9272
Email: dara@dwcomm.ca

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Prairie Plant Systems Comment on the New Medical Marijuana Regulations

Saskatoon, SK

For the Canadians who have come to rely on medical marijuana for symptom management due to chronic disabilities and terminal illnesses, Prairie Plant Systems has been the sole supplier to Health Canada for the last 13 years, and has been producing safe and consistent medical marijuana for thousands of Canadian patients.

With today’s official release of the Marihuana for Medical Purposes Regulations, the Harper Government has introduced revised regulations that will effectively create a new commercial industry responsible for providing access to quality controlled marijuana that is produced under the strictest of rules to ensure patient and public safety.

Prairie Plant Systems has already been operating under these strict manufacturing and quality controlled regulations and will continue to be Canada’s leading provider of marijuana for medical purposes.

“These new regulations allow us the flexibility to clinically study and introduce several additional product types (strains or varieties), allowing us to customize different tetrahydrocannabinol (THC) and cannabidiol (CBD) levels, providing better symptom relief targeted to specific patient needs,” said Brent Zettl, CEO, Prairie Plant Systems. “We welcome the opportunity to collaborate with the medical community and use our sophisticated research and development division to tailor personalized medicine for people with chronic disabilities and terminal illnesses, in an effort to improve quality of life.”

About Prairie Plant Systems and CanniMed®

Prairie Plant Systems’ CanniMed® medical marijuana is developed through rigorous health and safety standards. At Prairie Plant Systems, medical marijuana is produced under Good Manufacturing Practices (GMP) regulations, the criteria used to manufacture all pharmaceuticals in Canada.

What sets Prairie Plant Systems apart is our clinical trial program where we are making a concerted effort to close the gap between anecdotal benefit and evidence based medicine in order to standardize care. To date, the pharmaceutical grade cannabis produced by Prairie Plant Systems has been used in  published clinical trial results demonstrating the efficacy of smoked cannabis for chronic pain. 1 Additional clinical trials are currently underway using different medical marijuana varieties, in controlled medical conditions.

For more information please contact:

Dara Willis
Dara Willis Communications
Mobile: 416-836-9272

1 Ware, M. A., Wang, T., Shapiro, S., Robinson, A. and others. (2010) Smoked Cannabis for Chronic Pain: a Randomized Controlled Trial. Canadian Medical Association Journal (CMAJ). 182:E694-E701.

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Prairie Plant Systems has grown significantly through development and acquisition of our key subsidiary companies:

CanniMed Ltd.

CanniMed Ltd. was established in 2013 to provide Canadian patients with access to a standardized and trusted supply of pharmaceutical-grade cannabis under the Marihuana for Medical Purposes Regulations (MMPR) governed by Health Canada.

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SubTerra LLC

Sub Terra LLC is a plant-based pharmaceutical manufacturer committed to the production of Active Pharmaceutical Ingredients (APIs) such as high value proteins and phytochemicals.

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PPS Fruit Trees

Decades of research and development have made PPS a leading supplier of fruit trees to orchards around the world. Our continued commitment to excellence can be seen in the uncompromising quality of every plant PPS grows and sells.

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